Striker James Chamanga, midfielder Noah Chivuta and Kampamba Chintu have all been axed for the 2014 World Cup Group D qualifier.
Renard has otherwise kept faith in the majority of his players that have served him during his last two stints as Zambia coach.
However, another player missing will be defender Joseph Musonda who is serving a one-match suspension after accruing two yellow cards at the 2013 Africa Cup.
Meanwhile, Renard has named four home-based players in his 19-member team that includes Power Dynamos midfielder Mukuka Mulenga plus his team mate at Arthur Davies goalkeeper Joshua Titima.
Others are Zanaco midfielder Roderick Kabwe and his club mate in goalkeeper Racha Kola.
The team is expected to go into camp in Johannesburg on March 17.
Goalkeepers: Kennedy Mweene (Free State Stars, South Africa), Joshua Titima (Power Dynamos), Racha Kola (Zanaco)
Defenders: Stopilla Sunzu, Hichani Himonde (Both TP Mazembe), Davies Nkausu (SuperSport United, South Africa), Emmanuel Mbola (FC Porto, Portugal)
Midfielders: Chisamba Lungu (FC Ural, Russia), Mukuka Mulenga (Power Dynamos) Roderick Kabwe (Zanaco), Nathan Sinkala, Rainford Kalaba, Jonas Sakuwaha (All TP Mazembe, DR Congo), William Njobvu ( Be’er Sheva, Israel), Isaac Chansa (Henan Jianye, China)
Strikers: Emmanuel Mayuka (Southampton, England),Collins Mbesuma (Orlando Pirates, South Africa), Christopher Katongo (Henan Jianye, China), Jacob Mulenga (FC Utrecht, Holland)